Diversity of model organisms in physiology (6 ECTS)
The objective of this course is to introduce students to the concept of model organisms and model biological systems and the importance of selecting a model which is appropriate for a particular study question. Several examples will be covered for topics in cellular physiology, developmental biology, and plant and animal pathophysiology, including the design of new models (e.g. mutant or transgenic lines) to investigate the functioning of different genes. Finally, ethical issues raised by using animals as experimental subjects and the creation of GMOs (genetically modified organisms) in both fundamental and applied research (e.g. pharmaceutical, cosmetics industries...) will be discussed.
- Complexity of multicellular orgaisms, why we use organisms as models - their constraints and characteristics, types of model organisms and systems (animal and plant).
- Model organisms for animal and plant physiology, their genetic and biological characteristics.
- Model plants and animals: their particularities with respect to experimental, ethical and legislative issues.
- Experimental models in animal physiology: cell lines, trangenic models, strains from diseased animals, applications...
- Experimental models in plant physiology: cell and tissue cultures, protoplasts, culturing organ fragments and sensitivity testing to pathogens, applications...
- The future of models for biological systems.
Egalement dans la rubrique
Master Biologie intégrative et physiologie
9 quai Saint Bernard
75252 Paris cedex 05
Bât. B - 3e étage
Porte 314 - BC 118